3MB Psychiatry: Pharmacology
This flashcard set outlines key antidepressant types, including how monoamine oxidase inhibitors (MAOIs) work, and provides examples of commonly used tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs).
How do monamine oxidase inhibitors work? Give an example of one
Slow down breakdown of neurotransmitters by inhibiting MAO enzyme
Phenelzine
Key Terms
How do monamine oxidase inhibitors work? Give an example of one
Slow down breakdown of neurotransmitters by inhibiting MAO enzyme
Phenelzine
List some TCA’s
Amitriptyline
Clomipramine
Imipramine
Dosulepin
List some SSRI’s
Fluoxetine
Paroxetine
Citalopram
Sertraline
Whereabouts in the synapse do MAO inhibitors act?
Presynaptic terminal
Whereabouts in the synapse do TCA’s act?
Synaptic cleft
Whereabouts in the synapse do SSRI’s act?
Presynaptic terminal
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| Term | Definition |
|---|---|
How do monamine oxidase inhibitors work? Give an example of one | Slow down breakdown of neurotransmitters by inhibiting MAO enzyme |
List some TCA’s |
|
List some SSRI’s | Fluoxetine |
Whereabouts in the synapse do MAO inhibitors act? | Presynaptic terminal |
Whereabouts in the synapse do TCA’s act? | Synaptic cleft |
Whereabouts in the synapse do SSRI’s act? | Presynaptic terminal |
Which SSRI’s can inhibit CYP450 system? |
Paroxetine |
List some adverse effects of SSRI’s | Sexual dysfunction |
List some adverse effects of TCA’s | Constipation |
Which class of drug are major tranquilizers - antipsychotics or benzodiazepines? | Antipsychotics |
What is the general overall mechanism of benzodiazepines? | Act at GABA receptor mediate its inhibitory effect |
List the pharmacological clinical effects of benzodiazepines | Reduce anxiety and aggression |
Which BZD acts as a GABA receptor antagonist and what is its effect on anxiety? | Flumazenil Increases anxiety |
Some people can develop tolerance to BZD’s - what is the significance of this? | The doses that work for them can be lethal in normal people |
List the clinical effects of rapid withdrawal of BZD’s |
|