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BIOL1020 - Lecture 12 - Gene regulation in Eukaryotes

Anatomy and Physiology2 CardsCreated 3 months ago

This deck covers key concepts of gene regulation in eukaryotes, including the levels of regulation and the process of chromatin remodeling.

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what are the seven levels of gene regulation in eukaryotes?

1) chromatin remodelling 2) transcriptional control 3) RNA processing - 5’ capping, 3’ polyadenylation, splicing 4) RNA localisation 5) RNA stability and degradation 6) Translational control 7) Protein folding, post-translational modification NOT MUTUALLY EXCLUSIVE
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Key Terms

Term
Definition
what are the seven levels of gene regulation in eukaryotes?
1) chromatin remodelling 2) transcriptional control 3) RNA processing - 5’ capping, 3’ polyadenylation, splicing 4) RNA localisation 5) RNA stability ...
Describe chromatin remodelling.
> histone structure can be modified. Generally: - histone acetylation is associated with active chromatin - i.e., euchromatin, loose, easier to transc...
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BIOL1020 - Lecture 12 - Gene regulation in Eukaryotes
TermDefinition
what are the seven levels of gene regulation in eukaryotes?
1) chromatin remodelling 2) transcriptional control 3) RNA processing - 5’ capping, 3’ polyadenylation, splicing 4) RNA localisation 5) RNA stability and degradation 6) Translational control 7) Protein folding, post-translational modification NOT MUTUALLY EXCLUSIVE
Describe chromatin remodelling.
> histone structure can be modified. Generally: - histone acetylation is associated with active chromatin - i.e., euchromatin, loose, easier to transcribe -histone and especially DNA methylation (cytosines, methyl-C) inactive genes, i.e., heterochromatin, tightly condensed DNA e.g., in some cases cancer cells’ tumour suppressor genes are inappropriately repressed by methylation, and heterochromatin is activated by acetylation.