QQuestionAnatomy and Physiology
QuestionAnatomy and Physiology
Arrange the following events of coagulation in the correct order:
Damaged tissue or blood vessels release coagulation factors.
Factor X is activated.
Prothrombinase combines with factor X.
Prothrombin is converted to thrombin.
Fibrinogen is converted to fibrin.
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Answer
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Step 1
Damaged tissue or blood vessels release coagulation factors: When tissue is damaged or blood vessels are injured, coagulation factors stored in the damaged cells are released. These factors initiate the coagulation cascade.
Step 2
Factor X is activated: The extrinsic and intrinsic pathways of the coagulation cascade lead to the activation of factor X. In the extrinsic pathway, tissue factor (TF) released from damaged tissue binds to factor VIIa, activating factor X (Xa). In the intrinsic pathway, factor IXa, activated by factor VIIIa, forms the tenase complex that also activates factor X.
Final Answer
The correct order of events in the coagulation cascade is: 1. Damaged tissue or blood vessels release coagulation factors. 2. Factor X is activated. 3. Prothrombinase combines with factor X. 4. Prothrombin is converted to thrombin. 5. Fibrinogen is converted to fibrin.
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