1.9 Enzyme Inhibition
Competitive inhibitors resemble the substrate and temporarily bind to the active site, reducing enzyme activity—but their effect can be reduced by increasing substrate concentration. Non-competitive inhibitors bind elsewhere on the enzyme, altering the active site’s shape, and their effect remains unchanged regardless of substrate concentration.
Describe how competitive inhibitors work
similar molecular shape to the substrate
-bind to the active site to prevent the substrate from bindingnot permanent
Key Terms
Describe how competitive inhibitors work
similar molecular shape to the substrate
-bind to the active site to prevent the substrate from bindingnot permanent
...
What is the effect of increasing substrate concentration on competitive inhibitors?
the effect on the inhibitor is reduced
Describe how non competitive inhibitors work
Attach to a binding site which is not the active site
-Breaks bonds within the protein which alters the shape of the active site
-Sub...
what is the effect of increasing substrate concentration on non-competitive inhibitors
no effect as inhibitor and substrate are not competing for the same active site
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| Term | Definition |
|---|---|
Describe how competitive inhibitors work |
|
What is the effect of increasing substrate concentration on competitive inhibitors? |
|
Describe how non competitive inhibitors work |
|
what is the effect of increasing substrate concentration on non-competitive inhibitors | no effect as inhibitor and substrate are not competing for the same active site |