QQuestionAnatomy and Physiology
QuestionAnatomy and Physiology
Which of the following cross-couplings of an enolate is used to prepare the smoking cessation drug Chantix, which was spoofed on a Saturday Night Live skit?
Your answer
O a.Suzuki-Miyaura Coupling
O b.Heck reaction
O c.o-arylation
O d. Buchwald-Hartwig Amination
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Answer
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Step 1: Identify the reaction type used in the synthesis of Chantix.
Chantix, also known as varenicline, is a medication used for smoking cessation. It is an asymmetric amine, which suggests that its synthesis might involve an amination reaction. Among the given options, the Buchwald-Hartwig Amination (option d) is an amination reaction.
Step 2: Exclude other reaction types.
The Suzuki-Miyaura Coupling (option a) is a type of cross-coupling reaction used for the formation of carbon-carbon bonds between organoboron compounds and organic halides. The Heck reaction (option b) is another type of cross-coupling reaction that forms carbon-carbon bonds between organic halides and alkenes. The o-arylation (option c) is a type of cross-coupling reaction that forms carbon-carbon bonds between aryl halides and arenes. None of these reaction types result in an asymmetric amine, so they can be excluded.
Final Answer
The smoking cessation drug Chantix, which was spoofed on a Saturday Night Live skit, is prepared using the Buchwald-Hartwig Amination (option d).
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