2024-2025 Autoimmune hematologic Disorders (PEARLS) (Smarty PANCE) with Answers (45 Solved Questions)

Name: 2024-2025 Autoimmune hematologic Disorders (PEARLS) (Smarty PANCE) with Answers (45 Solved Questions)
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Autoimmune hematologic
disorders (PEARLS) (Smarty
PANCE) 100% VERIFIED
ANSWERS 2024/2025
CORRECT
Anemias can be broadly grouped into 3 categories based on what?
Anemias can be broadly grouped into 3 categories based on mean corpuscular
volume, or MCV, which reflects the volume of a red blood cell.
What are the 3 broadly grouped categories of anemia based on MCV?
1. Microcytic: MCV is lower than 80 fL,
2. Normocytic: MCV between 80 and 100 fL
3. Macrocytic: MCV larger than 100 fL.
Normocytic anemias can be further classified as what?
Normocytic anemias can be further classified as
1. Hemolytic when there's increased destruction of RBCs
2. Non-hemolytic when there's decreased production of RBCs from the bone marrow
Hemolytic anemia is a ___________?
Normocytic anemia

How do you distinguish between hemolytic and non-hemolytic normocytic
anemias?
When there's hemolysis, the bone marrow revs up and starts pumping out immature
RBCs called reticulocytes, but when there's a bone marrow problem reticulocyte count
is low. So for your exams, it's important to know that in hemolytic anemias there's an
increased reticulocyte production index of over 2%, while in non-hemolytic anemias it's
lower than 2%.
In hemolytic anemia the reticulocyte count will be _______?
High > 2%
How are hemolytic anemias classified?
Hemolytic anemias can be classified as intrinsic and extrinsic hemolytic anemias
Intrinsic hemolytic anemias?
In intrinsic hemolytic anemias, the RBCs are destroyed due to RBC membrane
defects, like
in hereditary spherocytosis and paroxysmal nocturnal hemoglobinuria, or PNH;
enzyme deficiencies, like in G6PD deficiency and pyruvate kinase deficiency; and
hemoglobin abnormalities, like in sickle cell anemia.
Extrinsic hemolytic anemias?
In extrinsic hemolytic anemias, the RBCs are normal but are later destroyed via
extrinsic mechanisms such as autoantibodies directed against RBCs. Extrinsic
hemolytic anemias that
include autoimmune hemolytic anemia, microangiopathic hemolytic anemia, macr
oangiopathic hemolytic anemia and infections.
How is intrinsic hemolysis divided?

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Physician Assistant National Certifying Exam

2024-2025 Autoimmune hematologic Disorders (PEARLS) (Smarty PANCE) with Answers (45 Solved Questions)

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