Medicine /Pharm Y2S2 - Radiopharmacy
What are the principles of nuclear medicine?
Used for functional purposes as opposed to anatomical Use pharmaceuticals with radioactive labels in small quantities to prevent interference Used mainly for diagnostic and research purposes
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Definition
What are the principles of nuclear medicine?
Used for functional purposes as opposed to anatomical Use pharmaceuticals with radioactive labels in small quantities to prevent interference Used mai...
What is the most common base for diagnostic radiopharmaceuticals?
Technetium Tc-99m
How are images acquired?
Using a gamma radiation camera
What are the ideal properties of a radioactive label?
Pure gamma-emmitter No particulate emissions Readily available, cheap production No unwanted effects Diverse chemistry allowing attachment to numerous...
What occurs in a radiopharmaceutical generator?
99MoO4(2-) is adsorbed onto alumina This decays to Tc-99m Partechnetate anion in acidic solution is absorbed by sites on alumina and displaced by adde...
What are the two possible sets of aseptic conditions for radiopharmacy units?
1- laminar flow cabinet at grade A with a grade B clean room 2- Isolator glove box with negative pressure at grade A in a grade D clean room
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Term | Definition |
---|---|
What are the principles of nuclear medicine? | Used for functional purposes as opposed to anatomical Use pharmaceuticals with radioactive labels in small quantities to prevent interference Used mainly for diagnostic and research purposes |
What is the most common base for diagnostic radiopharmaceuticals? | Technetium Tc-99m |
How are images acquired? | Using a gamma radiation camera |
What are the ideal properties of a radioactive label? | Pure gamma-emmitter No particulate emissions Readily available, cheap production No unwanted effects Diverse chemistry allowing attachment to numerous pharmaceuticals |
What occurs in a radiopharmaceutical generator? | 99MoO4(2-) is adsorbed onto alumina This decays to Tc-99m Partechnetate anion in acidic solution is absorbed by sites on alumina and displaced by added electrolytes |
What are the two possible sets of aseptic conditions for radiopharmacy units? | 1- laminar flow cabinet at grade A with a grade B clean room 2- Isolator glove box with negative pressure at grade A in a grade D clean room |
How is radio labelling achieved? | TcO4(-) must be lowered from +7 oxidation state The reduced species is highly reactive so a chelating agent is added |
What are the conditions of a manufacturer’s license for a radio pharmacy unit? | Specials license required Two people named on the license, one in charge of production and the other of quality control |
Under what circumstances is a manufacturer’s license not necessary? | Supervision by suitably trained pharmacist allows operation under section 10 exemptions of the Medicines Act |