Medicine /Simmons NURP 502 Exam 1 3: Asthma Medications Part 2

Simmons NURP 502 Exam 1 3: Asthma Medications Part 2

Medicine27 CardsCreated 29 days ago

This deck covers essential questions and answers about asthma medications, focusing on their classifications, uses, and effects. It is designed to help students understand the different types of asthma medications and their specific roles in treatment.

Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine? Symbicort

Combined ICS/LABA (Budesonide/Formoterol)
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Key Terms

Term
Definition
Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine? Symbicort
Combined ICS/LABA (Budesonide/Formoterol)
Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine? Advair
Combined ICS/LABA (Salmeterol/Fluticasone)
Prolonged use of albuterol is associated with what?
Tachyphylaxis d/t beta2-receptor downregulation and receptor hyposensitivity.
Nonracemic form of albuterol offers a significant reduction in which adverse effects?
Muscle tremors; Tachycardia; Hyperglycemia; Hypokalemia
T/F Levalbuterol is effective in smaller doses than albuterol.
True. And dose may be doubled in acute severe episodes.
SABAs are used for what 2 situations?
Treat bronchospasm in acute episodes. | Prevent bronchospasm in exercise-induced asthma.

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TermDefinition
Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine? Symbicort
Combined ICS/LABA (Budesonide/Formoterol)
Is this a SABA, anticholinergic, systemic corticosteroid, ICS, immunomodulator, leukotriene modifier, LABA, or methylxanthine? Advair
Combined ICS/LABA (Salmeterol/Fluticasone)
Prolonged use of albuterol is associated with what?
Tachyphylaxis d/t beta2-receptor downregulation and receptor hyposensitivity.
Nonracemic form of albuterol offers a significant reduction in which adverse effects?
Muscle tremors; Tachycardia; Hyperglycemia; Hypokalemia
T/F Levalbuterol is effective in smaller doses than albuterol.
True. And dose may be doubled in acute severe episodes.
SABAs are used for what 2 situations?
Treat bronchospasm in acute episodes. | Prevent bronchospasm in exercise-induced asthma.
Acts as bronchodilator by inhibiting muscarinic receptors and reduces vagal tone of airways.
Anticholinergics
Adjuvant therapy with SABA for treatment of acute exacerbations.
Anticholinergics
Works to inhibit secretions from serous and seromucous glands lining nasal mucosa.
Anticholinergic (applied locally)
Used for a short course (3-10 days) to gain control of poorly controlled episodes.
Systemic Corticosteroids
When are systemic corticosteroids used long-term?
Used for long-term prevention of symptoms in severe persistent asthma as well as for suppression, control, and reversal of inflammation.
What does a systemic corticosteroid do for SABAs?
It reverses the subsensitivity and downregulation of beta2 receptors from frequent and repetitive use of SABAs.
Which systemic corticosteroid is not associated with vomiting?
Dexamethasone
Preventive treatment of nocturnal asthma or exercise-induced asthmatic symptoms.
LABAs
T/F LABAs are stand-alone meds for both asthma and COPD.
False. They are never to be used alone in asthma. They are only used if other meds do not control asthma and must be used in combination with other meds.
Long-term control of symptoms. Suppression, control, and reversal of inflammation.
ICSs
Most potent anti-inflammatory agents but are least likely to cause adverse effects b/c poorly absorbed systemically.
ICSs
Adverse effects of ICSs.
• Oral candidiasis • Dysphonia • Reflex cough • Bronchospasm
How are adverse effects of ICS minimized?
With spacer and MDI.
Block late asthmatic response to allergens. Reduce airway hyperresponsiveness. Inhibit cytokine production, adhesion protein activation, and inflammatory cell migration and activation. Reverse beta2-receptor downregulation and subsensitivity.
ICS
How do leukotrienes cause problems?
bronchospasm, increased vascular permeability, mucosal edema, and inflammatory cells.
Long-term control and prevention of symptoms, especially nocturnal symptoms.
Methylxanthines
Causes bronchodilation and minimal anti-inflammatory properties. Less effective than ICSs. Potential toxicity, so monitor serum concentrations. Used infrequently.
Methylxanthines
Moderate-to-severe persistent asthma patients who react to perennial allergens. Symptoms are not controlled by inhaled corticosteroids.
Monoclonal Antibodies
Bind selectively to human IgE on the surface of mast cells and basophils.
Monoclonal Antibodies
This has a risk of severe allergic reaction and is only used in 12+ age group.
Omalizumab (Monoclonal Antibody)
Decrease asthma exacerbations when inhaled short-acting beta2-agonists and corticosteroids have failed.
Combined ICS/LABA