Bretylium
Inhibits release of NE
Key Terms
Bretylium
Inhibits release of NE
Cocaine Re NE
Inhibit re-uptake of NE
TCA Re NE
Inhibit re-uptake of NE
Amphetamine Re NE
Inhibit re-uptake of NE
Presynaptic Regulation of Noradrenergic nerve terminals
NE --> α2 --/ NE release
ATII --> NE release
ACh --> M2 --/ NE release
Bethanechol
MoA
Uses
Organs affected
Dynamics
Muscarinic agonist
PostOp ileus, Neurogenic ileus, Urinary retention
"Bethany Call me if you want to activate your Bowels or Bladder"
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| Term | Definition |
|---|---|
Bretylium | Inhibits release of NE |
Cocaine Re NE | Inhibit re-uptake of NE |
TCA Re NE | Inhibit re-uptake of NE |
Amphetamine Re NE | Inhibit re-uptake of NE |
Presynaptic Regulation of Noradrenergic nerve terminals | NE --> α2 --/ NE release ATII --> NE release ACh --> M2 --/ NE release |
Bethanechol MoA Uses Organs affected Dynamics | Muscarinic agonist PostOp ileus, Neurogenic ileus, Urinary retention "Bethany Call me if you want to activate your Bowels or Bladder" Activates Bowel and Bladder smooth muscle Resistent to AChE |
Carbachol MoA Uses Mnemonic | Muscarinic and Nicotinic Agonists Glaucoma, Pupillary Contraction, and Relief of Intraocular Pressure "CARBon copy of AcetylCHOLine" |
Pilocarpine MoA Affects Uses Organs affected Dynamics Mnemonic | Muscarinic Agonist Stimulator of sweat, tear, and salivary glands Open and closed angle glaucoma Contracts ciliary muscles of eye (closed angle glaucoma), Pupillary sphincter (closed angle glaucoma) Resistant to AChE "You Cry, Drool, and Sweat on your PILOw" |
Methacholine MoA Use | Muscarinic Agonist | Asthma challenge |
Neostigmine MoA Distribution Uses | Reversible AChE inhibitor "Neo CNS" No CNS penetration PostOp and neurogenic ileus and urinary retention, MG, Reversal of NMJ blockade PostOp |
Pyridostigmine MoA Uses Distribution | Reversible AChE inhibitor "Rid of MG." MG (long acting) Does not penetrate CNS |
Edrophonium MoA Uses | Reversible AChE inhibitor | Diagnosis of MG (short acting) |
Physostigmine MoA Distribution Uses | Reversible AChE inhibitor Crosses BBB Anticholinergic toxicity "PHYso PHYxes atropine poisoning" |
Donepezil Distribution Uses | Reversible AChE inhibitor CNS Alzheimer's Disease |
Risk of all AChE inhibitors | Exacerbation of COPD, Asthma, Peptic Ulcer Disease |
Cholinesterase Inhibitor Poisoning What is it? What causes it? Presentation Classic pt Antidote | Irreversible AChE inhibition Organophosphates like Parathion "DUMBBELSS" Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation (of skeletal muscle and CNS), Lacrimation, Sweating, Salivation Farmer working with insecticides Atropine + Pralidoxime (regenerates active AChE) |
Homatropine MoA Molecule like it? Organs affected? Uses | Muscarinic Antagonist Atropine, Tropicamide Eye Produces mydriasis and cycloplegia |
Benztropine MoA Organs involved Use | Muscarinic Antagonist CNS "PARK my BENZ" Parkinson's Disease |
Scopolamine MoA Organs involved Uses | Muscarinic Antagonist CNS Motion sickness |
Ipratropium MoA Molecules like it Organis involved Use | Muscarinic Antagonist Tiotropium Respiratory COPD and Asthma "I PRAY i can breath again" |
Oxybutynin MoA Organs involved Use | Muscarinic Antagonist GU Reduce urgency in mild cystitis and reduce bladder spasms |
Glycopyrrolate MoA Organs involved Use | Muscarinic Antagonist GU and Respiratory Parenteral: PreOp use to reduce airway secretions Oral: Drooling, Peptic Ulcers |
Atropine MoA Eye, Airway, Stomach, Gut, Bladder Presentation | Muscarinic Antagonist ↑ pupil dilation, cycloplegia (acute angle glaucoma in elderly) ↓ airway secretions, ↓ stomach acids, ↓ gut motility (constipation), ↓ bladder urgency Blocks DUMBBeLSS (excitation mediated by nicotinic receptors) |
Atropine Poisoning | Hot as a Hare Dry as a Bone Red as a Beat Blind as a Bat Mad as a Hatter |
What receptors does Epi affect? | What are its uses? | α1, α2, β1, β2 (β more) | Anaphylaxis, Open Angle Glaucoma, Asthma, Hypotension |