What receptors does NE affect?
| What are its uses?
α1, α2, β1 (α more)
| Hypotension (but ↓ Renal Perfusion)
Key Terms
What receptors does NE affect?
| What are its uses?
α1, α2, β1 (α more)
| Hypotension (but ↓ Renal Perfusion)
What receptors does Isoproterenol affect?
| What are its uses?
β1, β2
| Torsade de pointes, Bradyarrhythmias (but can worsen ischemia)
What receptors does DA affect?
| What are its uses?
α1, α2, β1, β2, D1
| Shock (renal perfusion) and heart failure
What receptors does Dobutamine affect?
| What are its uses?
α1, α2, β1, β2 (β1 way more so!)
| Heart failure, Cardiac stress test
What receptors does Phenylephrine affect?
| What are its uses?
α1 and α2 (α1 more)
| Hypotension, Ocular procedures (mydriatic), Rhinitis (decongestant)
What receptors does Albuterol affect?
Similar drugs?
What are its uses?
β1, β2 (β2 more so)
Salmeterol, Terbutaline
A: acute Asthma
S: long term Asthma, COPD
T: reduce premature uterine contracti...
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| Term | Definition |
|---|---|
What receptors does NE affect? | What are its uses? | α1, α2, β1 (α more) | Hypotension (but ↓ Renal Perfusion) |
What receptors does Isoproterenol affect? | What are its uses? | β1, β2 | Torsade de pointes, Bradyarrhythmias (but can worsen ischemia) |
What receptors does DA affect? | What are its uses? | α1, α2, β1, β2, D1 | Shock (renal perfusion) and heart failure |
What receptors does Dobutamine affect? | What are its uses? | α1, α2, β1, β2 (β1 way more so!) | Heart failure, Cardiac stress test |
What receptors does Phenylephrine affect? | What are its uses? | α1 and α2 (α1 more) | Hypotension, Ocular procedures (mydriatic), Rhinitis (decongestant) |
What receptors does Albuterol affect? Similar drugs? What are its uses? | β1, β2 (β2 more so) Salmeterol, Terbutaline A: acute Asthma S: long term Asthma, COPD T: reduce premature uterine contractions |
Ritodrine What receptors does it affect? Uses | β2 | Reduce premature uterine contractions |
Amphetamine MoA Uses | Release of stored Catecholamines | Narcolepsy, Obesity, ADD |
Ephedrine MoA Uses | Release of stored Catecholamines | Nasal decongestion, Urinary incontinence, Hypotension |
Cocaine MoA What does it lead to? Contraindications | Inhibits reuptake of catecholamines Vasoconstriction and local anesthesia β blockers contraindicated because can lead to unopposed α activation and HTN |
NE vs Isoproterenol | NE --> ↑ in systolic and diastolic BP α mediated vasoconstriction --> ↑ MAP --> Bradycardia Isoproterenol --> β2 mediated vasodilation --> ↓ MAP and ↑ HR through β1 and reflex activity |
Clonidine MoA Molecules similar to it? Uses | α2 agonist --> ↓ central sympathetic outflow α methyldopa HTN esp with Renal Disease |
Phenoxybenzamine MoA Reversibility Uses Tox | α blocker Irreversible Pheochromocytoma (PreOp) Orthostatic Hypotension and reflex Tachycardia |
Phentolamine MoA Reversibility Uses | α blocker Reversible Give to pts on MAO inhibitors who eat tyramine-containing foods |
α1 blockers Names Uses Tox | Prazosin, Terazosin, Doxazosin, Tamsulosin HTN, Urinary retention in BPH Orthostatic Hypotension, Dizziness, Headache |
α2 blockers Names Uses Tox | Mirtazapine Depression Sedation, ↑ Cholesterol, ↑ Appetite |
Phenylephrine vs Epi on α blockade | Epi will cause net decrease in BP because of actions on β | PE will cause a reversal to baseline because it is pure α |
β blockers Names Applications | Acebutolol, Betaxolol, Esmolol, Atenolol, Metolol, Propanolol, Timolol, Pindolol, Labetalol Angina Pectoris, MI, SVT (M and E ↓ conduction velocity), HTN (renin), CHF, Glaucoma (T ↓ secretion of aqueous humor) |
β blockers Tox | Use with caution in… | Bradycardia (AV block and CHF), Bronchoconstriction, Claudication, Lipids, Vivid dreams (seizures, sedation), Impotence, Masks hypoglycemia Use with caution in diabetics, ↓ insulin release Use with caution in diabetics |
β1 blockers | "A BEAM" Before M in the alphabet | Acebutolol, Betaxolol, Esmolol, Atenolol, Metoprolol |
Non selective β blockers | "Please Try Not βeing Picky" After M in the alphabet | Propanolol, Timolol,Nadolol, Pindolol |
α and β non selective blockers | Carvedilol, Labetalol |
Partial β Agonists | Pindolol, Acebutolol |