Q
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"The COI management plan aims to: Eliminate all COIs in research when a COI is disclosed Address disclosure of COIs in multi-center research when a COI is disclosed Reduce IRB review burden when a COI is disclosed Provide procedures or extras steps to be taken to minimize the risk of bias when a COI is disclosed"
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Step 1
: Understand the problem

The problem is asking for measures to be taken in response to the disclosure of Conflict of Interests (COIs) in research, specifically in the context of multi-center research. The goals are to eliminate COIs, address their disclosure, reduce the burden on Institutional Review Boards (IRBs), and minimize the risk of bias.

Step 2
: Eliminate all COIs in research when a COI is disclosed

When a COI is disclosed, it is essential to eliminate it to maintain the integrity of the research. This can be achieved by taking the following steps: - Require researchers to divest themselves of any financial interests that may be influencing their research. - Implement strict policies and procedures for managing COIs, including guidelines for reporting and addressing COIs. - Provide training and education to researchers on the importance of identifying and managing COIs.

Final Answer

To address COIs in research, the following measures should be taken: 1. Eliminate all COIs in research when a COI is disclosed by requiring researchers to divest themselves of any financial interests, implementing strict policies and procedures, and providing training and education. 2. Address disclosure of COIs in multi-center research when a COI is disclosed by establishing clear communication channels, requiring disclosure to all relevant parties, and implementing a system for tracking and managing COIs. 3. Reduce IRB review burden when a COI is disclosed by providing clear guidelines, establishing a streamlined process, and providing training and education. 4. Minimize the risk of bias when a COI is disclosed by implementing procedures for blinded data analysis and review, requiring disclosure of potential sources of bias, and providing training and education.

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