2024-2025 Anemias Disorders (PEARLS) (Smarty PANCE) with Answers (73 Solved Questions)
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Anemias (PEARLS) - Smarty
PANCE 100% VERIFIED
ANSWERS 2024/2025
Normal or ↓ MCV, ↓ TIBC, ↑ Ferritin (high iron stores) ↓ serum erythropoietin
Anemia of chronic disease
The only anemia where all three cell lines are decreased (pancytopenia) ↓ WBC, ↓
RBC, ↓ Platelets - will have normal MCV and ↓ Retic
Aplastic anemia
↓ Folate, ↑ MCV (macrocytic anemia) looks like B12 but no neurologic symptoms.
Common in alcoholics
Folate deficiency
After infection or medication in an African American male + Heinz Bodies and Bite
Cells on smear. Flare triggers: Fava beans, antimalarials, sulfonamides
G6PD deficiency
History of jaundice, transfusion, new medication or infection (+) direct coombs
test
Autoimmune Hemolytic anemia
↓ MCV (microcytic), ↑ TIBC, ↓ Ferritin (low iron stores) ↓ MCH (hypochromic).
Associated with pica and nail spooning, target cells
Iron deficiency
PANCE 100% VERIFIED
ANSWERS 2024/2025
Normal or ↓ MCV, ↓ TIBC, ↑ Ferritin (high iron stores) ↓ serum erythropoietin
Anemia of chronic disease
The only anemia where all three cell lines are decreased (pancytopenia) ↓ WBC, ↓
RBC, ↓ Platelets - will have normal MCV and ↓ Retic
Aplastic anemia
↓ Folate, ↑ MCV (macrocytic anemia) looks like B12 but no neurologic symptoms.
Common in alcoholics
Folate deficiency
After infection or medication in an African American male + Heinz Bodies and Bite
Cells on smear. Flare triggers: Fava beans, antimalarials, sulfonamides
G6PD deficiency
History of jaundice, transfusion, new medication or infection (+) direct coombs
test
Autoimmune Hemolytic anemia
↓ MCV (microcytic), ↑ TIBC, ↓ Ferritin (low iron stores) ↓ MCH (hypochromic).
Associated with pica and nail spooning, target cells
Iron deficiency
African American, pain, family history of blood disorder. Hemoglobin
electrophoresis: Hemoglobin S, Blood smear: Sickled RBCs, howell-Jolly bodies,
target cells
Sickle cell anemia
Microcytic hypochromic, elevated iron. Most severe, Mediterranean descent,
failure to thrive. Hemoglobin electrophoresis: Hemoglobin A2 and F.
Beta thalassemia major
Microcytic hypochromic, elevated iron. Mild anemia, often misdiagnosed as iron
deficient. Hemoglobin electrophoresis: Hemoglobin A2
Beta thalassemia trait
Chinese and southeast Asians. Hemoglobin electrophoresis: Hemoglobin H (H
disease), Hemoglobin Bart's (hydrops fetalis), Hemoglobin A (trait)
Alpha thalassemia
↑ MCV (macrocytic anemia), Hypersegmented Neutrophils and normal
folate, decreased vibratory and position sense
Vitamin B12 deficiency
Less than 10% radiolabeled vitamin B12 in urine. Normal results when repeated
with administration of intrinsic factor
Schilling test for the diagnosis of pernicious anemia (antibody to intrinsic factor)
What disorder is a hemoglobin electrophoresis result of "SS" indicative of?
Sickle cell disease
What disorder is a hemoglobin electrophoresis result of "SA" indicative of?
electrophoresis: Hemoglobin S, Blood smear: Sickled RBCs, howell-Jolly bodies,
target cells
Sickle cell anemia
Microcytic hypochromic, elevated iron. Most severe, Mediterranean descent,
failure to thrive. Hemoglobin electrophoresis: Hemoglobin A2 and F.
Beta thalassemia major
Microcytic hypochromic, elevated iron. Mild anemia, often misdiagnosed as iron
deficient. Hemoglobin electrophoresis: Hemoglobin A2
Beta thalassemia trait
Chinese and southeast Asians. Hemoglobin electrophoresis: Hemoglobin H (H
disease), Hemoglobin Bart's (hydrops fetalis), Hemoglobin A (trait)
Alpha thalassemia
↑ MCV (macrocytic anemia), Hypersegmented Neutrophils and normal
folate, decreased vibratory and position sense
Vitamin B12 deficiency
Less than 10% radiolabeled vitamin B12 in urine. Normal results when repeated
with administration of intrinsic factor
Schilling test for the diagnosis of pernicious anemia (antibody to intrinsic factor)
What disorder is a hemoglobin electrophoresis result of "SS" indicative of?
Sickle cell disease
What disorder is a hemoglobin electrophoresis result of "SA" indicative of?
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Physician Assistant National Certifying Exam