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Comprehensive Guide to Addiction Medications and T

This detailed chart outlines key addiction medications, their indications, neurotransmitter targets, side effects, dosing, and special considerations for age, pregnancy, and breastfeeding in the treatment of opioid and alcohol dependence.

Mason Bennett
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Addiction Medications TableWeek BCH O WBl. M NH M V n t M T V“HIS ASSIGNMENT SHOULD BE SUBMITTED TO THE WEEK 5 MEDICATION TABLE DROPBOX BY SUNDAY AT 11 59 P.M. MT.Drug NameIndicationNeurotransmitterfs)AffectedTarget SymptomsHalf-life (Tl'2),Metabolism (CYP 450enzyme)Notable Side Effects(link to NT or affectedbrain circuit)Initial DosingConsiderationsSpecific lifespanconsiderations(age, pregnancy,breastfeeding)Buprenorphine(Subutex)Indication:Maintenancetreatment of opioiddependenceMaintenancetreatment of opioiddependence inpatients who haveachieved andsustained prolongedclinical stability onlow-to moderatedoses of a transmucosalbuprenorphinecontaining productModerate to severeopioid use disorder inpatients who haveinitiated treatmentwith a transmucosal24-42hoursCYP450:CYP3A424-42hoursCYP450:CYP3A4Half-life: 24-42 hoursCYP450: CYP3A4Headache,constipation, nauseaOral hypoesthesia,glosscdyniaOrthostatichypotensionRespiratory distressHepatotoxicityBinds to mu opioidreceptorsInitial dosing:Sublingual 8-32mg dayControlled studieshave not beenconducted inpregnant women.Buprenorphinemay be preferableto methadone inpregnant women.Neonatal opioidwithdrawalsyndrome has beenreported followinguse ofBuprenorphineduring pregnancySome drag isbuprenorphinecontaining product,followed by doseadjustment for aminimum of 7 daysNeurotransmitteraffected: Mu opioidreceptor partialagonist Antagonist atthe kappa opioidreceptorTarget symptoms:Opioid dependencefound in mother'sbreast milk.Recommendedeither todiscontinued drugor formula feed.Use with cautionin elderly. Somepatients maytolerate lowerdoses better.Buprenorphine Naloxone(Suboxone, Zubsolv,Bunavail)Indication:Treatment, andmaintenance ofopioid dependence.Induction oftreatment for opioiddependenceMaintenancetreatment of opioiddependence inpatients who haveachieved andsustained prolongedclinical stability onlow-to moderateSuboxone: 24-42 hoursNaloxone: 2-12 hoursCYP450: CYP3A4Headache,constipation, nausea,oral hypcesthesia,glosscdynia,orthostatichypotension, sedationBinding at mu opioidreceptorsInitial dosing:Bunavail: Day 1:induction dose:Initial: Buccal:Buprenorphine 2.1mg naloxone 0.3mg; may repeatdose after 2 hours,based on control ofacute withdrawalsymptoms;maximum totaldose:buprenorphine 4.2mg naloxone 0.7mg. Day 2:

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Pharmacology

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