Test Bank For Integrated Cardiopulmonary Pharmacology, 3rd Edition, 3rd Edition

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Colbert_icp3_TestBank_questions.docPage 1 of 150Test BankChapter 1MULTIPLE CHOICEChoose the one alternative that best completes the statement or answers the question.1.Which term best describes the study of drugs and their action on the body?a.Therapeuticsb.Pharmacologyc.Pharmacotherapyd.Disease management2.The most common source of drugs today is:a.Plants.b.Animals.c.Chemical synthesis.d.Genetic bioengineering.3.The agency that regulates drug testing and approves new drugs is the:a.Center for Drug Evaluation and Research (CDER).b.Centers for Disease Control and Prevention (CDC).c.National Institutes of Health (NIH).d.Food and Drug Administration (FDA).4.The phase of drug testing that is performed to look for rare or serious adverse effects afterthe drug is marketed is:a. Phase I.b. Phase II.c. Phase III.d. Phase IV.5.What organization is officially responsible for establishing public standards that approveddrugs must continue to meet?a.ThePhysicians‟ Desk Reference (PDR)b.The American Hospital Formulary Service (AHFS)c.The United States Pharmacopeia (USP)d.The Food and Drug Administration (FDA)

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Colbert_icp3_TestBank_questions.docPage 2 of 1506.The name given to a drug that is considered the nonproprietary name and is not owned byany particular pharmaceutical company is the:a.Chemical name.b.Generic name.c.Trade name.d.Brand name..7.A 21-year-old pregnant female has been exposed to the drug Virazole, which has beenreported to cause damage to the fetus. This type of drug exposure is referred to as:a.An adverse drug reaction (ADR).b.A life-threatening reaction.c.Hypersensitivity.d.Teratogenicity.8.Drugs that do not go directly into the systemic circulation after being absorbed and aremetabolized through the liver describes a:a.Steady state.b.First-pass effect.c.Therapeutic range.d.Half-life.9.A physician would like a patient to receive acetaminophen via the enteral route. Yourchoice of administration may include:I.Oral.II.Nasogastric.III.Rectal.a.Ib.I and IIc.I and IIId.I, II, and III10.Administration of 80 mg propranolol given orally (PO) produces the same response as 1mg intravenously (IV). The difference in dosage is explained by:a.The first-pass effect.b.Bioavailability.c.Protein binding.d.Metabolism.11.The most common and convenient route of drug administration is:a.Oral.b.Inhalation.c.Sublingual.d.Transdermal.

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Colbert_icp3_TestBank_questions.docPage 3 of 15012.A malnourished patient is susceptible to an increase in drug response because of allexcept which of the following?a.A malnourished patient has less serum albumin.b.The free, unbound drug is an active drug and will lead to greater drug response.c.Less drug is absorbed systemically.d.Much of the drug will be free within the bloodstream.13.The effect of administering a water-soluble drug to an infant, who has a higherpercentage of total body water compared to an adult, would be:a.Decreased effect.b.The same effect.c.Increased effect.d.An additive effect.14.The mechanisms responsible for metabolism of rifampin in the liver include:I.Drug oxidation.II.Enzyme inhibition.III.The cytochrome P-450 system.a.I and IIb.I and IIIc.II and IIId.I, II, and III15.After drugs are metabolized, they can be eliminated from the body through the:a.Skin.b.Lungs.c.Feces and urine.d.All of the above.16.The potency of a drug is best described as:a.An affinity of the drug for a particular receptor site.b.The degree in which the drug can be cleared from the body.c.The route of the drug.d.The amount of drug required to produce the response desired.17.Excretion of drugs through the kidneys is affected by all except which of the following?a.Glomerular filtrationb.Drug oxidationc.Impaired renal functiond.Tubular secretion and reabsorption18.When a drug binds to a receptor site, all except which of the following can occur?a.An ion channel can be opened or closed.b.Biochemical messengers that initiate chemical reactions can be activated.c.A normal cellular function can be turned on or off.

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Colbert_icp3_TestBank_questions.docPage 4 of 150d.The therapeutic response produced is directly proportional to the number of sitesoccupied.19.A drug that does not elicit a response:a.Is an agonist.b.Increases drug action.c.Is an antagonist.d.Activates the receptor.20.A cell that becomes less responsive to a drug after exposure over time is a conditioncalled:a.Tolerance.b.Desensitization.c.Dependence.d.Low therapeutic index.21.You note that a physician has made a new entry on a patient‟s chart. The entry reads “500mg acetaminophen PO QID.” What does this order mean?a.500 mg acetaminophen by mouth, four times dailyb.500 mg acetaminophen per order, six times dailyc.500 mg acetaminophen preop, then dailyd.500 mg acetaminophen postop, then every 4 hours22.Which of the following routes of drug administration completely bypasses the absorptionstep before entering the bloodstream?a.Oralb.Rectalc.Intravenousd.Intramuscular23.To maintain a steady state of drug concentration in the plasma, a drug should beadministered by which of the following methods?a.Intramuscular injectionb.Continuous IV infusionc.Intravenous bolusd.Transdermally24.Which of the following terms explains why a patient may require an increased amount ofa drug after repeated use to produce the same therapeutic effect?a.Dependenceb.Selectivityc.Tachyphylaxisd.Tolerance25.Treatment for drug overdoses and poisoning includes all of the following except the:

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Colbert_icp3_TestBank_questions.docPage 5 of 150a.Administration of antidotes.b.Use of an adsorbent.c.Administration of emetics.d.Use of a metabolite.TRUE/FALSEWrite „T‟ if the statement is true and „F‟ if the statement is false.______ 1.The FDA considers herbals the same as drugs because they are derived fromplants that were forerunners of many current medications.______ 2.An interaction between two drugs that causes one drug to have no direct effectbut increases the response of the other drug is referred to as the drug‟s potency.______ 3.Administration of a drug directly to the lungs is a form of topical delivery.______ 4.Continuous infusion gives a regulated, consistent dosage over time, referred to asa steady state. On the other hand, a bolus dose causes fluctuations in the plasma drugconcentration.______ 5.As a drug increases in selectivity to a particular cell or tissue, the less useful itbecomes.______ 6.Fat-soluble drugs have a decreased effect in patients who are obese.______ 7.For a drug to be excreted from the body, it has to be metabolized so that it iswater soluble.______ 8.Liver function tests should be conducted to determine if a patient can metabolizea prescribed drug.______ 9.Emetics are agents that are administered to induce vomiting in the event ofpoisoning.______10.A formulary is a list of drugs that a particular health care system stocks anddispenses.FILL-IN-THE-BLANKWrite the word or phrase that best completes each statement.1.A severe, life-threatening allergic reaction can result in ________________.2.Drugs administered directly to the lungs are given via the ____________ route.3.Drugs given parenterally go directly to the ________________ and result in rapidabsorption.4.Repeated use of the same drug may result in a decreased response, requiring an increasedamount of the drug to produce the same effect. This phenomenon is known as________________.5.In order for digoxin to be effective, an appropriate amount of the drug must be present inthe blood. This blood level is known as the ________________.6.The _______________ name of a drug is the name assigned by the United StatesAdopted Name (USAN) Council.

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Colbert_icp3_TestBank_questions.docPage 6 of 1507.Drugs that are released slowly once administered are referred to as _______________formulations.8.Patients who are ordered nothing by mouth but are prescribed a medication to be givenenterally may be administered the drug _____________.9.Biotransformation occurs when drugs are converted to a ____________ form forelimination.10.In order for drugs to be effective without causing toxicity, they must be maintainedwithin the ____________.SHORT ANSWERAnswer the following questions or statements.1.What is the difference between an endogenous and exogenous chemical?2.Explain the difference in how agonist and antagonist drugs react once combined with areceptor.3.Why are patients with liver disease likely to have greater than expected effects fromprescribed drugs?4.What is the purpose of a “do not use” list of common abbreviations?5.What basic safeguards should be followed in order to reduce medication administrationerrors?

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Colbert_icp3_TestBank_questions.docPage 7 of 150Chapter 2MULTIPLE CHOICEChoose the one alternative that best completes the statement or answers the question.1. A patient with a tidal volume of 400 milliliters has a tidal volume of how many liters?a.40b.4c..400d..042.A patient who weighs 55 kilograms is to receive a drug dosage of 10mg/kg. How muchdrug should be administered?a.550 mgb.250 mgc25 mgd.5.5 mg3.A patient‟s height is reported as 5 feet 6 inches. What is the patient‟s height incentimeters?a.26 cmb.30 cmc.145 cmd.167 cm4.A solution of drug contains 80 units/ml. How many milliliters would you need to deliver320 units of the drug?a.0.4 mlb.4 mlc.14 mld.40 ml5.A newborn‟s length at birth is measured as45.7 centimeters. What is the newborn‟slength in inches?a.17 inb.18 inc.19 ind.20 in6.While preparing an aerosol bronchodilator for a patient, you place 0.5 ml of a 1% drugsolution into a small-volume nebulizer. If you add 5 ml of saline instead of 2 ml of saline, thedelivered dose of drug will:a.Increaseb.Decreasec.Remain the samed.Weaken the drug response7.What is the percentage strength of 20 mg of cromolyn sodium in 2 ml of normal saline?

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Colbert_icp3_TestBank_questions.docPage 8 of 150a.1%b.2%c.10%d.20%8.If a drug order is written for 0.25 mg/kg of body weight, what dosage would beadministered to a patient weighing 88 lb?a.10 mgb.22 mgc.40 mgd.44 mg9.A dosage of 4 mg of morphine sulfate is ordered for a patient. How many milliliters willbe administered from a vial containing 10 mg/ml?a.0.1 mlb.0.4 mlc.1 mld.4 ml10.An adult female patient weighs 125 lb. In order to determine a mechanical tidal volume,you must convert her weight to kilograms. What is her weight in kilograms?a.275 kgb.63 kgc.57 kgd.28 kg11.You have just assisted in the care of a premature infant who weighs 600 g. The baby‟smother asks you what the weight is in pounds. You calculate the baby‟s weight as:a.4.1 lbb.3.5 lbc.2.7 lbd.1.3 lb12.A medication bag contains 0.03 liters. This is equal to how many milliliters?a.3b.30c.300d.3,00013.A patient who is 5-feet-10 inches tall is how many centimeters tall?a.286 cmb.32 cmc.154 cmd.178 cm14.A homogeneous mixture of two or more substances is referred to as:a.Dissolved.

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Colbert_icp3_TestBank_questions.docPage 9 of 150b.A solvent.c.A solute.d.A solution.15.Virazole is supplied in a powder form that must be mixed with normal saline or sterilewater prior to nebulization. This type of solution represents a:a.Solid/solventb.Weight/volumec.Liquid/soluted.Volume/volume16.How much solute is in 3 ml of a 1:100 weight/volume solution?a.10 mlb.10 mgc.20 mld.30 mg17.Which of the following terms is a synonym for“active ingredient”?a.Solutionb.Solutec.Solventd.Saline18.What would the new concentration be, in percentage, of 1.5 ml of a 10% solution that hasbeen increased to 3.0 ml with normal saline?a.0.05%b.0.5%c.5%d.20%19.How much active drug is in 3 ml of a 10% solution?a.0.3 gb.1 gc.0.3 mgd.1 mg20.A rescue dosage of surfactant calls for 3 ml/kg body weight. If a premature infant weighs1,500 g, how many milliliters are needed?a.5.0 mlb.9.0 mlc.0.45 mld.4.5 ml21.If a drug contains 6% active ingredient, how many grams of the active ingredient wouldyou need in a 30-ml dose?a.18 gb.36 g

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Colbert_icp3_TestBank_questions.docPage 10 of 150c.1.8 gd.3.6 g22.Promazine comes in a 550-mg/10-ml liquid solution. How many milliliters are needed togive a 200-mg dose?a.3.6 mlb.30 mlc.0.3 mld.3 ml23.Terbutaline sulfate is available as 1 mg/1 ml in an ampule. How many milliliters areneeded to administer a 0.75 dose?a.1.5 mlb.0.75 mlc.0.15 mld.0.30 ml24.What strength of drug would be administered if 6 g of active ingredient is reconstitutedwith sterile water to a total volume of 300 ml?a.2% strengthb.0.5% strengthc.20% strengthd.50% strength25.You receive an order for 16 gtt of Mucomyst. How many milliliters of drug would you beadministering to the patient?a.0.5 mlb.1 mlc.1.5 mld.5 mlTRUE/FALSEWrite „T‟ if the statement is true and „F‟ if the statement is false.______ 1.The Joint Commission recommends that a zero always be placed after thedecimal point when referring to drug dosage.______ 2.The method used to convert between the English and metric systems is referredto as the factor-label method.______ 3.Normal saline in solution with albuterol is known as the solvent.______ 4.When a solute is being dissolved in a powder, the solution is termed avolume/volume solution.______ 5.When calculating drug dosages based on a patient‟s weight in kilograms, arespiratory therapist can use the BSA nomogram to convert from pounds to kilograms.______ 6.The International System is the system of measure used in health care.

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Colbert_icp3_TestBank_questions.docPage 11 of 150______ 7.Converting a measure from milliliters to liters is accomplished by moving thedecimal point three places to the right.______ 8.A solute can either be a liquid or a solid that is dissolved in a liquid.______ 9.A weight/volume solution is representative of the amount of liquid solute in avolume of solution.______10.The use of body surface area (BSA) is an appropriate method to determine apatient‟s overall size.FILL-IN-THE-BLANKWrite the word or phrase that best completes each statement.1.The metric unit of measurement for length is ________________, and the metricmeasurement for volume is ________________.2.One kilogram equals ________________ pounds.3.A liquid or solid that is dissolved in a solution is known as a ________________.4.A 1:200 solution of a drug would contain ________________ ml of the solute dissolvedin ________________ ml of solution.5.The strength of a 5-g/100-ml solution expressed as a ratio is 1:________________.6.The metric system of measurement is based on the __________________.7.The United States Customary System of Measurement is based on the _______________.8.Weight is measured as ____________ or ________________ in the metric system.9.To convert from liters to milliliters the decimal point is moved ___________ places tothe ___________.10.The Joint Commission standards recommend the use of ________________ rather thancentimeters (cc) to avoid misinterpretation of the ordered amount.SHORT ANSWERAnswer the following questions or statements.1.What do Joint Commission standards recommend for abbreviating cubic centimetervolume?2.Give an example of converting between the English and metric systems using the factor-label method.3.Explain the difference between a weight/volume solution and a volume/volume solution.4.How can you express the strength of a drug in solution?5.How can you determine how much drug to administer if the drug available is not suppliedin the prescribed amount?

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Colbert_icp3_TestBank_questions.docPage 12 of 150Chapter 3MULTIPLE CHOICEChoose the one alternative that best completes the statement or answers the question.1.All of the following explain the function of the somatic nervous system except:a.Skeletal muscle movement.b.Conduction of sensory information.c.Involuntary control.d.Voluntary movement.2.The sympathetic system causes which of the following effects?a.Bronchoconstrictionb.Increased digestionc.Decreased heart rated.Bladder relaxation3.The ANS regulates all the following body functions except:a.Digestion.b.Skeletal muscle movement.c.Cardiac muscle control.d.Blood vessel constriction.4.Bronchodilation is achieved by using which of the following classifications of drugs?I.ParasympatholyticII.SympatholyticsIII.Adrenergic agonistsa.I and IIb.II and IIIc.I and IIId.I, II, and III5.The peripheral nervous system is composed of all the following except:a.Afferent and efferent nerves.b.Brain and spinal nerves.c.Sympathetic and parasympathetic branches.d.The somatic and autonomic nervous systems.6.The somatic nervous system is responsible for:a.Skeletal muscle movement.b.Cardiac muscle control.c.The digestive process.d.Involuntary muscle control.7.Which statement best explains the control of the parasympathetic and sympatheticsystems?a.The parasympathetic and sympathetic systems work independently of each otherto regulate autonomic control.

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Colbert_icp3_TestBank_questions.docPage 13 of 150b.The sympathetic system is in primary autonomic control.c.The parasympathetic and sympathetic systems work in a coordinated, oppositefashion to maintain balance.d.The parasympathetic system is the dominant controller.8.The system responsible for a rise in heart rate and blood pressure when your instructorannounces a surprise quiz is the:a.Central.b.Parasympathetic.c.Somatic.d.Sympathetic.9.The systems responsible for maintaining coordination between bronchodilation andbronchoconstriction are the:a.Parasympathetic and sympathetic.b.Somatic and autonomic.c.Peripheral and autonomic.d.Autonomic and sympathetic.10.Which of the following cannot be considered part of a two-junction system?a.The somatic nervous systemb.The norepinephrine neurotransmitterc.Postgangliad.The autonomic nervous system11.Norepinephrine is found at the terminal end of which of the following nerve fibers?a.Preganglionic junction of the sympathetic systemb.Postganglionic junction of the sympathetic systemc.Preganglionic junction of the parasympathetic systemd.Postganglionic junction of the parasympathetic system12.The primary action of neurotransmitters takes place at the:a.Neuroeffector site.b.Presynaptic neuron.c.Postsynaptic neuron.d.Nerve axon.13.In a situation of stress, any of the following receptors may be stimulated except:a.Adrenergic.b.Muscarinic.c.Nicotinic.d.Beta.14.If you apply the alpha-adrenergic agent phenylephrine topically, which of the followingoccurs?a.Swollen vessels constrict.b.Blood pressure decreases.c.Heart rate decreases.d.Respiratory rate increases.

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Colbert_icp3_TestBank_questions.docPage 14 of 15015.A physician has just written an order for atropine to be administered to a patient forwhich you are caring. This parasympatholytic drug would cause all the following except:a.Bronchodilation.b.Dry secretions.c.Bradycardia.d.Vasoconstriction.16.Receptors that bind with acetylcholine can be referred to as:I.Cholinergic.II.Adrenergic.III.Muscarinic.IV.Nicotinic.a.I and IIb.I and IIIc.I, II, and IIId.I, III, and IV17.Receptors that bind with norepinephrine are referred to as:I.Adrenergic.II.Alpha.III.Beta.IV.Muscarinic.a.I and IIb.I, II, and IIIc.I and IVd.II, III, and IV18.Stimulation of dopamine receptors causes which of the following?a.Increased heart rateb.Relaxation of renal arteriesc.Constriction of peripheral blood vesselsd.Bronchodilation19.The primary action of sympathomimetics is to:a.Stimulate acetylcholine.b.Block acetylcholine.c.Stimulate norepinephrine.d.Block norepinephrine.20.The name of the parasympathetic neurotransmitter is:a.Acetylcholine.b.Cholinesterase.c.Norepinephrine.d.Adrenalin.21.Drugs that antagonize the sympathetic response would be classified as all of thefollowingexcept:

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Colbert_icp3_TestBank_questions.docPage 15 of 150a.Antiadrenergics.b.Sympatholytics.c.Beta blockers.d.Muscarinics.22.Beta1stimulation mainly affects the:a.Heart.b.Blood vessels.c.Airways.d.Skeleton and muscles.23.Beta2stimulation results in:a.Bronchospasm.b.Bronchodilation.c.Vasoconstriction.d.Vasodilation.24.A drug that is classified as a beta blocker would cause which of the following effects?a.Vasodilationb.Increased heart ratec.Increased respirationsd.Bronchoconstriction25.Drugs that antagonize or block the parasympathetic response are referred to as:a.Antiadrenergics.b.Cholinergics.c.Parasympathomimetics.d.Parasympatholytics.26.When a drug stimulates a receptor, it can be classified as all the following except:a.Direct acting.b.An agonist.c.Sympathomimetic.d.Parasympatholytic.27.Agents that inhibit the enzyme acetylcholinesterase cause which of the following effectson the PNS?a.Bradycardia and hypotensionb.Overstimulation of the sympathetic branch of the PNSc.Noned.Bronchodilation28.Elimination of norepinephrine at the synaptic cleft is accomplished by which of thefollowing mechanisms?I.ReuptakeII.Metabolization by AChEIII.Metabolization by MAO

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