Psychology 115: Neuropsychopharmacology

Study of how drugs affect the brain and behavior.

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Psychology 115: NeuropsychopharmacologySpring 2015-Practice ExamPage1Psychology 115: NeuropsychopharmacologySpring 2015-Practice ExamStudent Name:___________________________________Permanent Number:_____________________Part A. True or False (1 mark each):As indicated on your Parscore sheets, fill in A for True or B for False.1. The efficacy of an agonist is determined in large part by the number of available or “active” receptorswith which to bind.TRUE!2. The Ras-Raf-MAP kinase pathway is activated upon stimulation of receptor tyrosine phosphatases.FALSE! (kinase, Trk-Rs)3. Intracellular signaling through Gq-coupled receptors does not involve direct activation of secondmessenger systems.TRUE! … (PLC-BETAPI(4,5)P2DAG/IP3then Ca2+.... PKC)Multiple Choice Answers (1 mark each):You are to select theBESTof the lettered alternatives provided for each question. Fill in the appropriateselection on your Parscore sheet.Choose onlyONEanswer for each question. Each question is worth 1mark each.4. Of the following, which is TRUE regarding receptors?a) A receptor has an endogenous ligand that interacts with a specific site on the receptor.b) The capacity of a ligand to bind to a receptor is determined by the charge, shape and size ofboth the ligand and the receptor.c) The intensity of the effect of the binding of a ligand to a receptor depends upon the percent oftotal receptor occupied by the ligand.d) All of the above.5. Activation of which of the following kinases is dependent upon intracellular cAMP levels?a) protein kinase A (PKA)b) protein kinase C (PKC)c) mitogen-activated protein kinase (MAPK)d) calcium-calmodulin kinase II (CAMK II)Open-ended Questions.Good answers should be concise and logically organized. Answers should bewritten on each page under the appropriate question and can continue to the back if necessary. Answerscan be in point form or can be illustrated but the information MUST be complete in order to receive fullmarks. Use the number of points awarded for each question as a guide for the number of steps involved.You have a full page to answer each question below but should you need more space, please use the backof the page but INDICATE so (or else a portion of your answer may be missed).6. Explain in detail at least 2 ways in which stimulation of a receptor tyrosine kinase could lead to anincrease in CREB-mediated transcription of a gene .(16 marks)

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