Psychology 115: Neuropsychopharmacology
Study of how drugs affect the brain and behavior.
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Psychology 115: Neuropsychopharmacology—Spring 2015- Practice Exam
Page 1
Psychology 115: Neuropsychopharmacology—Spring 2015- Practice Exam
Student Name:___________________________________
Permanent Number:_____________________
Part A. True or False (1 mark each):
As indicated on your Parscore sheets, fill in A for True or B for False.
1. The efficacy of an agonist is determined in large part by the number of available or “active” receptors
with which to bind. TRUE!
2. The Ras-Raf-MAP kinase pathway is activated upon stimulation of receptor tyrosine phosphatases.
FALSE! (kinase, Trk-Rs)
3. Intracellular signaling through Gq-coupled receptors does not involve direct activation of second
messenger systems. TRUE! … (PLC-BETA → PI(4,5)P2 → DAG/IP3 → then Ca2+.... PKC)
Multiple Choice Answers (1 mark each):
You are to select the BEST of the lettered alternatives provided for each question. Fill in the appropriate
selection on your Parscore sheet. Choose only ONE answer for each question. Each question is worth 1
mark each.
4. Of the following, which is TRUE regarding receptors?
a) A receptor has an endogenous ligand that interacts with a specific site on the receptor.
b) The capacity of a ligand to bind to a receptor is determined by the charge, shape and size of
both the ligand and the receptor.
c) The intensity of the effect of the binding of a ligand to a receptor depends upon the percent of
total receptor occupied by the ligand.
d) All of the above.
5. Activation of which of the following kinases is dependent upon intracellular cAMP levels?
a) protein kinase A (PKA)
b) protein kinase C (PKC)
c) mitogen-activated protein kinase (MAPK)
d) calcium-calmodulin kinase II (CAMK II)
Open-ended Questions. Good answers should be concise and logically organized. Answers should be
written on each page under the appropriate question and can continue to the back if necessary. Answers
can be in point form or can be illustrated but the information MUST be complete in order to receive full
marks. Use the number of points awarded for each question as a guide for the number of steps involved.
You have a full page to answer each question below but should you need more space, please use the back
of the page but INDICATE so (or else a portion of your answer may be missed).
6. Explain in detail at least 2 ways in which stimulation of a receptor tyrosine kinase could lead to an
increase in CREB-mediated transcription of a gene . (16 marks)
Page 1
Psychology 115: Neuropsychopharmacology—Spring 2015- Practice Exam
Student Name:___________________________________
Permanent Number:_____________________
Part A. True or False (1 mark each):
As indicated on your Parscore sheets, fill in A for True or B for False.
1. The efficacy of an agonist is determined in large part by the number of available or “active” receptors
with which to bind. TRUE!
2. The Ras-Raf-MAP kinase pathway is activated upon stimulation of receptor tyrosine phosphatases.
FALSE! (kinase, Trk-Rs)
3. Intracellular signaling through Gq-coupled receptors does not involve direct activation of second
messenger systems. TRUE! … (PLC-BETA → PI(4,5)P2 → DAG/IP3 → then Ca2+.... PKC)
Multiple Choice Answers (1 mark each):
You are to select the BEST of the lettered alternatives provided for each question. Fill in the appropriate
selection on your Parscore sheet. Choose only ONE answer for each question. Each question is worth 1
mark each.
4. Of the following, which is TRUE regarding receptors?
a) A receptor has an endogenous ligand that interacts with a specific site on the receptor.
b) The capacity of a ligand to bind to a receptor is determined by the charge, shape and size of
both the ligand and the receptor.
c) The intensity of the effect of the binding of a ligand to a receptor depends upon the percent of
total receptor occupied by the ligand.
d) All of the above.
5. Activation of which of the following kinases is dependent upon intracellular cAMP levels?
a) protein kinase A (PKA)
b) protein kinase C (PKC)
c) mitogen-activated protein kinase (MAPK)
d) calcium-calmodulin kinase II (CAMK II)
Open-ended Questions. Good answers should be concise and logically organized. Answers should be
written on each page under the appropriate question and can continue to the back if necessary. Answers
can be in point form or can be illustrated but the information MUST be complete in order to receive full
marks. Use the number of points awarded for each question as a guide for the number of steps involved.
You have a full page to answer each question below but should you need more space, please use the back
of the page but INDICATE so (or else a portion of your answer may be missed).
6. Explain in detail at least 2 ways in which stimulation of a receptor tyrosine kinase could lead to an
increase in CREB-mediated transcription of a gene . (16 marks)
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Document Details
University
Strayer University
Subject
Psychology