Test Bank For Pathophysiology of Disease: An Introduction to Clinical Medicine, 8th Edition

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Pathophysiology of Disease: An Introduction toClinical Medicine, Testbank/StudyguideChapter 1:IntroductionMULTIPLE CHOICE1.Which of the following would be the most likely cause of an iatrogenic disease?a.An inherited disorderb.Acombination of specific etiological factorsc.An unwanted effect of a prescribed drugd.Prolonged exposure to toxic chemicals in the environmentANS:C2.The manifestations of a disease are best defined as the:a.subjective feelings ofdiscomfort during a chronic illness.b.signs and symptoms of a disease.c.factors that precipitate an acute episode of a chronic illness.d.early indicators of the prodromal stage of infection.ANS: B3.The best definition of thetermprognosisis the:a.precipitating factors causing an acute episode.b.number of remissions to be expected during the course of a chronic illness.c.predicted outcome or likelihood of recovery from a specific disease.d.exacerbations occurring during chronic illness.

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ANS:C4.Which of the following is considered a systemic sign of disease?a.Swelling of the kneeb.Feverc.Pain in the neckd.Red rash on the faceANS: B5.Etiology is defined as the study ofthe:a.causes of a disease.b.course of a disease.c.expected complications of a disease.d.manifestations of a disease.ANS: A6.A type of cellular adaptation in which there is a decrease in cell size is referred to as:a.hypertrophy.b.metaplasia.c.anaplasia.d.atrophy.ANS: D7.A change in a tissue marked by cells that vary in size and shape and show increased mitoticfigures would be called:

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a.metaplasia.b.atrophy.c.dysplasia.d.hypertrophy.ANS: C8.A deficit of oxygen in the cells usually due to respiratory or circulatory problems is called:a.apoptosis.b.ischemia.c.hypertrophy.d.necrosis.ANS: B9.When a group of cells in the body dies, the change iscalled:a.ischemia.b.gangrene.c.hypoxia.d.necrosis.ANS: D10.Rigorous weight lifting/body building regimens may result in the skeletal muscle cellsundergoing:a.hypertrophy.b.dysplasia.

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c.atrophy.d.regeneration.ANS: A11.The termcancerrefers to:a.dysplasia.b.hyperplasia.c.metaplasia.d.malignant neoplasm.ANS: D12.To which of the following does the termapoptosisrefer?a.Increased rate of mitosis by certain cellsb.Ischemic damage to cellsc.Liquefaction of necrotic tissued.Preprogrammed cell self-destructionANS:D13.Which of the following statements is TRUE?a.Alteration of DNA does not change cell function.b.Damaged cells may be able to repair themselves.c.All types ofcells die at the same rate.d.Mild ischemia causes immediate cell death.ANS: B

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14.Caseation necrosis refers to an area where:a.cell proteins have been denatured.b.cell are liquefied by enzymes.c.dead cells form a thick cheesysubstance.d.bacterial invasion has occurred.ANS: C15.Routine application of sun block to skin would be an example of:a.an iatrogenic cause of cancer.b.a preventive measure.c.a precipitating factor.d.a predisposing condition.ANS: B16.A circumstance that causes a sudden acute episode of a chronic disease to occur is termed:a.latent stage.b.predisposing factor.c.incidence.d.precipitating factor.ANS: D17.The termhomeostasisrefers to:a.the causativefactors in a particular disease.b.maintenance of a stable internal environment.

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c.a condition that triggers an acute episode.d.a collection of signs and symptoms.ANS: B18.Which term is used to describe a new and secondary oradditional problem that arises afterthe original disease has been established?a.Symptomsb.Occurrencec.Manifestationsd.ComplicationANS: D19.Pathophysiology involves the study of:a.the structure of the human body.b.thefunctions of various organs in the body.c.functional or structural changes resulting from disease processes.d.various cell structures and related functions.ANS: C20.Which of the following is the best definition of epidemiology?a.Thescience of tracking the occurrence and distribution of diseasesb.The relative number of deaths resulting from a particular diseasec.Identification of a specific disease through evaluation of signs /symptomsd.The global search for emergingdiseasesANS: A

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21.Which of the following can cause cell injury or death?1. Hypoxia2. Exposure to excessive cold3. Excessive pressure on a tissue4. Chemical toxinsa.1, 2b.2, 4c.1, 3, 4d.1, 2, 3, 4ANS: D22.All of thefollowing are part of the Seven Steps to Health EXCEPT:a.follow cancer screening guidelines.b.use sun block agents whenever exposed.c.participate in strenuous exercise on a regular daily basis.d.choose high fiber, lower fat foods.ANS:C23.The termdiseaserefers to:a.the period of recovery and return to a normal healthy state.b.a deviation from the normal state of health and function.c.the treatment measures used to promote recovery.d.a basic collection of signs andsymptoms.

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ANS: B24.A collection of signs and symptoms, often affecting more than one organ or system, thatusually occur together in response to a certain condition is referred to as a (an):a.acute disease.b.multiorgan disorder.c.syndrome.d.manifestation.ANS: C25.All of the following statements are correct about cell damage EXCEPT:a.The initial stage of cell damage often causes an alteration in metabolic reactions.b.If the factor causing the damage is removed quickly, the cell may be able to recover andreturn to its normal state.c.If the noxious factor remains for an extended period of time, the damage becomes irreversibleand the cell dies.d.Initially, cell damage does not change cell metabolism, structure, or function.ANS: D26.Which of the following conditionsdistinguishes double blind studies used in health research?a.Neither the members of the control group or the experimental group nor the personadministering the treatment knows who is receiving the experimental therapy.b.Both groups of research subjects and the person administering the treatment know who is

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receiving the experimental therapy.c.The research subjects do not know, but the person administering the treatment knows who isreceiving placebo or standard therapy.d.Only members of the control group know they are receiving standard therapy.ANS: A27.If the data collected fromthe research process confirm that the new treatment has increasedeffectiveness and is safe, this is called:a.the placebo effect.b.evidence-based research.c.blind research studies.d.approval for immediate distribution.ANS: B28.Ashort-term illness that develops very quickly with perhaps a high fever or severe pain iscalled:a.acute.b.latent.c.chronic.d.manifestation.ANS: A29.The termprognosisrefers to the:a.period of recovery and return to a normal state.

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b.expected outcome of the disease.c.mortality and morbidity rates for a given population.d.typical collection of signs and symptoms.ANS: B30.When prolonged ischemia occurs to an area of the heart, the resulting damage is referred toas:a.atrophy.b.liquefactive necrosis.c.apoptosis.d.infarction.ANS: D31.During the evaluation process for a new therapyseffectiveness and safety, a double blindstudy may be conducted during:a.the first stage.b.the second stage.c.the third stage.d.any of these stages.ANS: C32.Why are the predisposing factors for a specific disease important to healthprofessionals?a.To predict the prognosisb.To determine treatmentsc.To develop preventive measures

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d.To develop morbidity statisticsANS: C33.Cell damage may be caused by exogenous sources such as:a.abnormal metabolic processes.b.certain food additives.c.genetic defects.d.localized hypoxia.ANS: B34.Which of the following is usually included in a medical history?1. Past illnesses or surgeries2. Current illnesses, acute and chronic3. Prescribed medication or othertreatments4. Nonprescription drugs and herbal remedies5. Current allergiesa.1, 3b.2, 4, 5c.1, 3, 4d.1, 2, 3, 4, 5ANS: D35.A situation when there is a higher than expected number of cases of an infectious diseasewithin a given area iscalled a/an:

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a.epidemic.b.exacerbation.c.morbidity.d.pandemic.ANS: A36.The termpathogenesisrefers to:a.the development of a disease or sequence of events related to tissue changes involved in thedisease process.b.the determination of the cause(s) involved in the development of a malignant neoplasm.c.the specific signs and symptoms involved in the change from an acute disease to a chronicdisease.d.the changes in cells of affected tissue that result in necrosis.ANS: A

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•Chapter 2:Genetic Disease•MULTIPLECHOICE•1.Which of the following statements applies to the sex chromosomes?a.They are identified as XY in thefemale.b.They are numbered pair 23 in the karyotype.c.They contain the same genes as in the other pairs of chromosomes.d.They are found only in the cells in the gonads (the ovaries and the testes).•ANS: B•2.What is the term for an arrangement of the chromosomes from an individuals cell,organized in pairs based on size and shape?a.Pedigreeb.Punnett squaresc.Karyotyped.Genotype•ANS: C•3.What is characteristic of a congenital disorder?a.Genes are not involved.b.It is strictly a developmental anomaly.c.A cause is known.d.It is usually manifested in the neonatal period.•ANS: D•4.What is the probability of two parents, both carriers of a defective recessive gene,producing a homozygous child (with each pregnancy)?

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a.0%b.25%c.50%d.75%•ANS: B•5.In the case of an X-linked recessive disorder, a carrier mother and unaffected fathercould produce a/an:a.normal female.b.affected female.c.malecarrier.•ANS: A•6.Down syndrome is an example of a/an:a.autosomal dominant disorder.b.multifactorial disorder.c.developmental defect.d.chromosomal disorder.•ANS: D•7.Agents that cause damage during embryonic or fetal development arecalled:a.teratogenic.b.mutagenic.c.multifactorial agents.

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d.polygenic agents.•ANS: A•8.What is an example of a multifactorial congenital disorder?a.Type AB bloodb.Down syndromec.Color blindnessd.Cleft lip and palate•ANS: D•9.Ultrasonography during pregnancy would be helpful in detecting fetal:a.enzyme deficits.b.structural anomalies.c.chromosomal defects.d.hormonal abnormalities.•ANS: B•10.Which of the following statements regarding Down syndrome is TRUE?a.The typical physical characteristics are present at birth.b.All children with Down syndrome have the same organ defects and medical problems.c.The extent of cognitive impairment can be assessed at birth.d.The birth of a child with Downsyndrome is only a risk to mothers over age 35.•ANS: A•11.Which of the following statements applies to Huntingtons disease?

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a.The effects are obvious at birth.b.There is a test for the defective gene.c.There is a 50% probability that thechild of an affected parent will be a carrier.d.The child must inherit the defective gene from both parents in order to be affected.•ANS:B•12.A mother is a carrier of Duchenne muscular dystrophy; the father is unaffected. Theyhave one son withmuscular dystrophy. Another male child is expected. The probabilityof the second son having muscular dystrophy is:a.100%b.50%c.25%d.0%•ANS: B•13.Hemophilia A has been diagnosed in a young boy. He has inherited this defectivegene from:a.his father.b.his mother.c.both parents.•ANS: B•14.A father affected with hemophilia A, whose wife is unaffected, will pass on thedefective gene to:a.all of his sons, who will be affected.

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b.50% of his sons, who will be affected.c.all ofhis daughters, who will be carriers.d.50% of his daughters, who will be carriers.•ANS:C•15.Which of the following are common manifestations of Down syndrome?•1. Congenital heart defect•2. Cleft lip and palate•3. Large protruding tongue•4.Limited intellectual developmenta.1, 2b.1, 3c.2, 4d.1, 3, 4•ANS: D•16.A spontaneous alteration in genetic material that may result from exposure to harmfulsubstances is termed:a.autosome.b.genotype.c.meiosis.d.mutation.•ANS: D•17.A person with sickle cell trait that is heterozygous has:a.an incomplete dominant gene.

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b.a multifactorial condition.c.co-dominant genes.d.X-linked dominant trait.•ANS: A•18.TORCH is an acronym for routine prenatalscreening tests for high-risk maternalinfections; TORCH stands for:a.toxoplasmosis, other (hepatitis B, mumps, rubeola, varicella, gonorrhea, syphilis), rubella, cytomegalovirus, andherpes.b.tuberculosis, other (hepatitis B, mumps, rubeola, varicella, gonorrhea, syphilis), rabies, cytomegalovirus, and HIV.c.toxoplasmosis, other (hepatitis B, mumps, rubeola, varicella, gonorrhea, syphilis), rabies, cytomegalovirus, and HIVd.tuberculosis,other (hepatitis B, mumps, rubeola, varicella, gonorrhea, syphilis), rabies, cytomegalovirus, and herpes•ANS: A•19.Which statement applies to the effects of exposure to harmful substances duringembryonic life?•1. During the first two weeks,exposure will usually cause death of the embryo.•2. Organs or body structures may be altered by exposure during the first two months.•3. The effects of exposure depend on the stage of development at the time of exposure.•4. Metabolic abnormalities usuallyfollow exposure to teratogens.a.1, 3b.2, 4c.1, 2, 3d.2, 3, 4•ANS: C•20.Exposure to cocaine during pregnancy leads to increased risk of:

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a.premature birth.b.respiratory problems.c.sudden infant death syndrome.d.A, B, and C•ANS: D•21.Which term refers to prenatal diagnosis through examination of amniotic fluid?a.Chorionic villus testingb.Preparing a family pedigreec.Amniocentesisd.Triple-screen test•ANS: C•22.The laboratory practice of changing DNAsequences in microorganisms is called:a.the genotype.b.gene mutation.c.genetic engineering.d.gene therapy.•ANS: C•23.The purpose of the Human Genome Project was to:a.map the nucleotide sequence and identify the genes on each humanchromosome.b.study the common patterns of inheritance of single-gene disorders.

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c.manipulate the sequence of DNA in microorganisms and animals.d.identify spontaneous alterations in genetic material caused by teratogens.•ANS: A•24.Developmental disorders can result from all the following EXCEPT:a.exposure to radiation.b.mercury in foods and water.c.drugs and alcohol.d.folic acid.•ANS: D•25.Genes located at the same site on a pair of homologous chromosomes that arealsomatched for function are called:a.alleles.b.genotypes.c.autosomes.d.phenotypes.•ANS: A•26.Which of the following can easily pass through the placental barrier?a.Many virusesb.Some heavy metalsc.Certain chemicalsd.All of theabove

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•ANS: D•27.The termproteomicsrefers to the study of:a.DNA sequences with unknown functions.b.gene sequences in individual chromosomes.c.the proteins resulting from activation of specific genes.d.identifying certain base pairs inDNA.•ANS: C•28.The most invasive prenatal screening test for fetal abnormalities is:a.ultrasonography.b.amniocentesis.c.X-ray.d.blood tests.•ANS: B•29.Which of the following can be detected using amniotic fluid?a.Chromosomalabnormalitiesb.Metabolic disordersc.Certain structural abnormalitiesd.All the above•ANS: D•30.Blood tests are performed on neonates primarily to:a.determine need for immediate surgical correction of anomalies.

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b.identify disordersrequiring immediate treatment.c.identify the presence of any inherited disorders.d.rule out the presence of any infection.•ANS: B•31.When genetic influences combine with environmental factors to cause anabnormality, the result is called a:a.chromosomal disorder.b.developmental disorder.c.multifactorial disorder.d.single-gene disorder.•ANS: C•32.The cellular division process that produces the chromosomes that are in the spermand ova is called:a.meiosis.b.mitosis.c.organogenesis.d.polysomy.•ANS: A

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•Chapter 3:Disorders of the Immune System•MULTIPLECHOICE•1.Neutrophils:a.are phagocytic cells.b.produce histamine.c.produce antibodies.d.are elevated during an allergic response.•ANS: A•2.Which cells are required to process and present antigens from foreign material as theinitial step in the immune response?a.Thelper cellsb.Macrophagesc.Eosinophilsd.Monocytes•ANS: B•3.Humoral immunity is mediated by:a.natural killer cells.b.T lymphocytes (T cells).c.B lymphocytes (B cells).d.neutrophils.•ANS: C•4.A secondary immune response differs from theprimary immune response in that:

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a.it is more rapid than the primary response and results in higher antibody levels.b.it is slower than the primary response and doesnt change the antibody levels.c.it occurs at the same time as the primaryresponse but results in a decrease in antibodies.d.it only occurs in hyperallergic reactions and results in a decrease of antibodies.•ANS: A•5.Which type of immunity is provided by a vaccination?a.Active naturalb.Active artificialc.Passive naturald.Passive artificial•ANS: B•6.When an allergen binds with IgEantibodies on mast cells, resulting in release ofchemical mediators, this reaction is called:a.cytotoxic hypersensitivity.b.immune complex hypersensitivity.c.type I hypersensitivity.d.type IV hypersensitivity.•ANS: C•7.The role ofmemory cells is to:a.change into an antibody-secreting cell following activation.b.immediately secrete antibodies following the first exposure to antigen.

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c.recognize the antigen and stimulate the immune response.d.bind complement to the antibody.•ANS: C•8.Which statement applies to contact dermatitis?a.It occurs when IgE antibodies on the skin react with the causative substance.b.It may result from ingested foods.c.Urticaria(hives) gradually spread over the body.d.A type IV reaction occurs in affected areas.•ANS: D•9.Which of the following causes anaphylaxis?a.A severe, systemic allergic reactionb.Type III hypersensitivityc.Cell-mediatedhypersensitivityd.Immune complex deposits in many tissues•ANS: A•10.Following a positive HIV antibodies blood test and ELISA test, what is the testcommonly used for confirmation?a.Agglutinationb.Double immunodiffusion testc.Western blottestd.Sedimentation rate test

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•ANS: C•11.Incompatible blood transfusions result in:a.hemolysis of erythrocytes.b.a type I immune response.c.deposits in multiple organs.d.immune deficiency.•ANS: A•12.An autoimmune disease is:a.excessive formation of antibodies following exposure to foreign material.b.an extreme response to normally harmless material in the environment.c.an abnormal response to ingested food and drugs.d.failure of the immune system to distinguish self from nonself.•ANS:D•13.Systemic lupus erythematosus is caused by:a.a chronic allergic condition.b.development of an immune-deficient state.c.a deficiency of T lymphocytes.d.immunecomplex deposits of antinuclear antibodies.•ANS: D•14.Distinguishing clinical features of systemic lupus erythematosus include:a.inflammation in multiple organs.

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b.lack of a specific diagnostic blood test.c.acute onset andnonprogressive course.d.typical skin rash on the chest and back.•ANS: A•15.Which of the following are the target cells for HIV?a.Helper T lymphocytes (CD4 lymphocytes)b.B lymphocytesc.Natural killer cellsd.Macrophages•ANS: A•16.Adiagnosis of HIV positive means that:a.the number of T lymphocytes in the circulating blood is decreased.b.significant opportunistic infection is present in the body.c.the individual has AIDS.d.the virus and its antibodies are present in theblood.•ANS: D•17.HIV infection impairs:a.humoral immunity.b.cell-mediated immunity.c.both humoral and cell-mediated immunity.

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d.neither type of immunity.•ANS: C•18.Immunodeficienciesmay result in an increased risk of infections by normallyharmless microorganisms. These infections are referred to as:a.opportunistic.b.prophylactic.c.abnormal.d.transient.•ANS:A•19.Serious infections frequently occurring inpatients with AIDS include:•1. tuberculosis.•2.Pneumocystiscariniipneumonia.•3. influenza.•4. tetanus.a.1, 2b.1, 4c.2, 3d.3, 4•ANS:A•20.Which of the following statements does NOT apply to major histocompatibilitycomplex (MHC)proteins or molecules?a.They are genes on chromosome 6.b.All members of a family have identical MHCs.

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c.They alert the immune system to virus-infected cells.d.A close match is essential for successful tissue transplants.•ANS: B•21.CD4-positive helper T cells function by:a.direct cytotoxic action.b.facilitating all immune system activity.c.producing immunoglobulins.d.inactivating allergens.•ANS: B•22.Host-versus-graft disease refers to:a.hyperacuterejection of tissue.b.T cells in grafted tissue attacking host cells.c.infection resulting from immunosuppression therapy.d.transplant rejection by the recipients immune system.•ANS: D•23.Which of the following complications does NOToccur frequently in AIDS patients?a.Kaposis sarcomab.Wasting syndromec.Lymphomad.Polyarthritis

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•ANS: D•24.Which of the following characteristics apply to HIV?•1. It contains two strands of DNA.•2. It tends to mutate frequently to form newstrains.•3. The incubation period is extremely short.•4. It is inactivated by heat and many disinfectants.a.1, 2b.1, 3c.2, 4d.3, 4•ANS: C•25.In cases of HIV infection, the window period refers to the time between:a.entry of the virusinto the blood and the initial manifestations.b.entry of the virus into the body and the appearance of antibodies in the blood.c.entry of the virus into the body and a significant drop in CD4 T-helper lymphocyte count.d.diagnosis of HIV positive and diagnosis of AIDS.•ANS:B•26.Which of the following is an effect of cytokines? They:a.activate and stimulate proliferation of B and T lymphocytes.b.destroy antigens quickly.c.increase the rate of mitosis in tumors.d.cause immediatepain.•ANS: A

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