Psychotherapy: 98b/100b - Schizophrenias
This flashcard set outlines the neurobiology and treatment principles of schizophrenia. All antipsychotic medications work by inhibiting dopamine signaling, which is central to managing both positive and negative symptoms. A delusion is defined as a fixed, false belief that may be bizarre (violates physical laws) or non-bizarre (possible but untrue).
What is the general mechanism of action of every antipsychotic medication?
Inhibit dopamine signaling
(Dopamine signaling is implicated in both positive and negative symptoms of schizphrenia)
Key Terms
What is the general mechanism of action of every antipsychotic medication?
Inhibit dopamine signaling
(Dopamine signaling is implicated in both positive and negative symptoms of schizphrenia)...
What is a delusion?
Firmly held, fixed, false belief
Can be bizzare or non-bizzare
(Bizzare violates the ...
Dopamine dysregulation in the mesocortical dopamine tract results in [positive/negative] symptoms
Dopamine dysregulation in the mesolimbic dopamine tract results in [positive/negative] symptoms
Dopamine dysregulation in the mesocortical dopamine tract results in negative symptoms
Dopamine dys...
What is the most common psychotic disorder?
Schizophrenia
What changes can be seen in the brain of a person with schizophrenia?
Volume loss
Changes in interneurons
Enlarged ventricles
Thalamic and hippocam...
What are the diagnostic criteria for schizophrenia?
2+ of the following for >6 months, resulting in marked impairment in role function
Delusions
Hallucinations
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| Term | Definition |
|---|---|
What is the general mechanism of action of every antipsychotic medication? | Inhibit dopamine signaling (Dopamine signaling is implicated in both positive and negative symptoms of schizphrenia) |
What is a delusion? | Firmly held, fixed, false belief Can be bizzare or non-bizzare (Bizzare violates the laws of physics; non-bizzare is physically possible) |
Dopamine dysregulation in the mesocortical dopamine tract results in [positive/negative] symptoms Dopamine dysregulation in the mesolimbic dopamine tract results in [positive/negative] symptoms | Dopamine dysregulation in the mesocortical dopamine tract results in negative symptoms Dopamine dysregulation in the mesolimbic dopamine tract results in positive symptoms |
What is the most common psychotic disorder? | Schizophrenia |
What changes can be seen in the brain of a person with schizophrenia? |
No neurodegeneration!! Schizophrenia is caused by abnormal neuronal migration during development, not neurodegeneration Affects both white and grey matter |
What are the diagnostic criteria for schizophrenia? | 2+ of the following for >6 months, resulting in marked impairment in role function
|
What is the difference between a positive symptoms and a negative symptom of schizophrenia? List some examples of each |
|
Which neurotransmitter is implicated in patients with schizophrenia and psychosis? | Dopamine
Serotonin, NMDA are likely also involved |
Describe the pathophysiology of schizophrenia | Impaired neuronal migration during development
NOT neurodegenerative |
What are the risk factors for schizophrenia? |
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