Protein Structure

Explore the levels of protein structure and understand how functional groups like amine and carboxyl groups influence protein folding, function, and interactions.

Daniel Miller
Contributor
4.3
39
4 months ago
Preview (4 of 11 Pages)
100%
Purchase to unlock

Page 1

Protein Structure - Page 1 preview image

Loading page image...

Protein StructureWhat are the levels of protein structure and what role do functional groups play?Proteins accomplish many cellular tasks such as facilitating chemical reactions, providing structure, andearning information from one cell tc another. How a protein chain coils up and folds determines itsthree-dimensional shape. Its shape will, in turn, determine how it interacts with other molecules and thusperforms its function in the cell.Model 1- Formation of a Peptide Bonda. Circle an amine group in the diagram, {click the picture and select edit to doso for this and ALL other drawing questions)b. Draw a triangle around a carboxylic acid (carboxy!} group.2. How are the amino acids similar to one another?eaCV t o(U-enWCRY H Y 'R M W e dA M wW vOCJ-tVX(MW,CRVkrSY IcjVo\K?

Page 2

Protein Structure - Page 2 preview image

Loading page image...

3. How are the amino acids different from one another?ivn- t AYIJWC4. How many amino acids are involved in the reaction to make a dipeptide?5. In Model 1 the original amino acids are combined through a condensation reaction tomake the dipeptide.a. What does Ri represent in the dipeptide?b. What does R 2represent in the dipeptide?MWijt I -6. Put a box around the atoms in the amino acids that become the H:O molecule producedby the reaction in Model 1.7. A peptide bond is a covalent bond linking two amino acids together in a peptide.a.Circle the peptide bond in Model 1.b.Between which two atoms in the dipeptide is the peptide bond located?c.Between what two functional groups is the peptide bond located?8. There are 22 different amino acids found in nature. Two were shown in Model 1.Additional examples are shown below. With your group, write one or two grammaticallycorrect sentences to describe how these amino acids are similar and how they are differentUse the terms R-group, amine group, and carboxyl group in your description.HIH j N— G— COUHHGlycine(Gly)Cysteine(Cn)Asparagine(A*n)Phenylalanine(Phe)

Page 3

Protein Structure - Page 3 preview image

Loading page image...

Model 2 - Protein Structure (Part A)Primary StructureAmino acid sequence: Ser-Tyr-Ala-Phe - Vai-Cys-Tyr-Asp-Cys - GlyPeptide structure:Secondary Structure<>il

Page 4

Protein Structure - Page 4 preview image

Loading page image...

9. Locate the primary structure of the polypeptide in Model 2.a.Draw an arrow to two different peptide bonds in the diagram.b.Circle three separate amino acids that were joined together to make thepolypeptide.10. The first five amino acids in this polypeptide are serine, tyrosine, alanine,phenylalanine, and valine, in that order (Ser-Tyr-Ala-Phe-Val). If the amino acids werechanged or rearranged (i.e., to Val-Phe-Ala-Ser-Tyr), the polypeptide would have adifferent name and identity. With your group, use this information to write a definition ofthe primary structure of a protein.CXtkeXAM A M11. Locate the secondary protein structure in Model 2.a.What types of bonds are holding the secondary structure in place?b.What groups on the amino acids are always involved in these bonds?MVx)( A M A< A A M 1A-4-12. Draw a rectangle around two different R groups on the amino acids in the secondarystructure in Model 2.13. Is there any interaction between R groups in the secondary structure in Model 2?(Jo14. Secondary protein structure can take the form of an alpha(a)-helix or a beta{b)-pleatedsheet, as illustrated below.a.Which drawing represents an a-helix, Molecule 1 or Molecule 2? Explain your reasoning.WuteMAjX-e,H - IroftdsbWhich drawing represents a b-pleated sheet? Explain your reasoning.Mokculc 1Molecule2
Preview Mode

This document has 11 pages. Sign in to access the full document!

Study Now!

XY-Copilot AI
Unlimited Access
Secure Payment
Instant Access
24/7 Support
Document Chat

Document Details

Subject
Biology

Related Documents

View all