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Exploring DNA Profiling

Learn how DNA profiling helps identify individuals through unique genetic patterns. This student activity explores real-world applications like forensics and genealogy using simulations and key concepts like STRs and gel electrophoresis.

Daniel Miller
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Student Exploration: DNA ProfilingDirections: Follow the instructions t o g o through the simulation. Respond to the questions andprompts in the orange boxes.Vocabulary:DNA polymerase, DNA profiling, gel electrophoresis, gene, mutation, non-coding region,polymerase chain reaction, primer, short tandem repeatPrior Knowledge Questions(Do these BEFORE using the Gizmo.)In 1985, Darryl Hunt was convicted of murder. While Hunt was in jail, a new method for analyzing DNAevidence was invented. The DNA evidence on the victim did not match Hunt's DNA but did match that ofanother prisoner. After 19 years spent behind bars. Hunt was finally declared innocent and released fromprison in 2004.1.DNA is used to tell people apart. What aspects ofDNA do you think make this possible?2.What are some possible uses for technology thatidentify people based on their DNA?The different arrangements/sequences of basepairs help create differences in our DNAcanDNA fingerprinting can be used to identifysuspects and link them to crime scenes, or theDNA found in our saliva can be used ingenealogy and help determine ethnic origins.GizmoWarm-upDNA profiling does not just compare people's entire genome side by side.Instead, a very particular part of the DNA is compared. In the DNAProfilingGizmo you will leam about the differences in DNA that make DNA profilingpossible and you will use that knowledge to design your own DNA profilingtest.Clickonthe crime lab in theForensic trainingsection You are looking atastrand ofDNA. DNAcontainsgenesandnon-coding regionsbetween genes Click onNon-coding A.1.You are looking at a portion of the non-coding Asection for three different people. Are these sectionsthe same or different? ExplainThese sections are different as some sectionsare different in length and have different basepair sequences.Person 1 and 3 have identical sequences intheir gene, whereas person 2 has a differentnucleotide sequence.2.Click Previous then click on Gene A. Are theredifferences in gene A for the three people?

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Biology

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