Chapter 6 Lecture Notes

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BIOX-110 - Anatomy & PhysiologyThomas Jefferson UniversityChapter 6:Skeletal System: Bones and Bone Tissue Lecture Notes6.1 Functions of the Skeletal System1.The skeletal system consists of bones, cartilage, tendons, and ligaments.2.The skeletal system supports the body, protects the organs it surrounds, allows body movements, stores mineralsand fats, and is the site of blood cell production.6.2 Cartilage1.Chondroblasts produce cartilage and become chondrocytes. Chondrocytes are located in lacunae surrounded bymatrix.2.The matrix of cartilage contains collagen fibers (for strength) and proteoglycans (to trap water).3.The perichondrium surrounds cartilage.□The outer layer contains fibroblasts.□The inner layer contains chondroblasts.4.Cartilage grows by both appositional and interstitial growth.6.3 Bone HistologyBone Matrix1.Collagen provides flexible strength.2.Hydroxyapatite provides compressional strength.Bone Cells1.Osteoblasts produce bone matrix and become osteocytes.□Osteoblasts connect to one another through cell processes and surround themselves with bone matrix tobecome osteocytes.□Osteocytes are located in lacunae and are connected to one another through canaliculi.2.Osteoclasts break down bone (with assistance from osteoblasts).3.Osteoblasts originate from osteochondral progenitor cells, whereas osteoclasts originate from stem cells in redbone maiTow.4.Ossification, the formation of bone, occurs through appositional growth.Woven and Lamellar Bone1.Woven bone has collagen fibers oriented in many directions. It is remodeled to form lamellar bone.2.Lamellar bone is arranged in thin layers, called lamellae, which have collagen fibers oriented parallel to oneanother.Spongy and Compact Bone1.Spongy bone has many spaces.ULamellae combine to form trabeculae, beams of bone that interconnect to form a latticelike structure withspaces filled with bone marrow and blood vessels.□The trabeculae are oriented along lines of stress and provide structural strength.2.Compact bone is dense, with few spaces.□Compact bone consists of organized lamellae: Circumferential lamellae form the outer surface of compactbones; concentric lamellae surround central canals, forming osteons; interstitial lamellae are remnants oflamellae left after bone remodeling.□Canals within compact bone provide a means for exchanging gases, nutrients, and waste products. Fromthe periosteum or endosteum, perforating canals carry blood vessels to central canals, and canaliculiconnect central canals to osteocytes.6.4 Bone AnatomyStructure of a Long Bone1.The diaphysis is the shaft of a long bone, and the epiphyses are distinct from the diaphysis and house theepiphyseal plate.2.The epiphyseal plate is the site of lengthwise bone growth.3.The medullary cavity is a space within the diaphysis.4.Red marrow is the site of blood cell production, and yellow marrow consists of fat.5.The periosteum covers the outer surface of bone.□The outer layer contains blood vessels and nerves.Topics, Figures and Tables listed in the Lecture Notes arc referencing your Textbook, Seeley's Anatomy & Physiology (13111edition),McGraw Hill LLC.1

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