Genetics: A Conceptual Approach, 6th Edition Solution Manual
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Answers to Chapter Opening and End-of-Chapter Think-Pair-Share Questions: Pierce Genetics 6e
Chapter 1
Think-Pair-Share questions for the chapter opening story:
Albinism occupied a special place in the Hopi culture; individuals who possessed this
trait were valued by members of the tribe. What are some examples of genetic traits that,
in contrast, sometimes result in discrimination and prejudice?
Possible Answers: People with many genetic traits are exposed to discrimination and
prejudice. Indeed, people with albinism in cultures other than the Hopis are subjected to
discrimination for the way they look. In the past, African Americans who were
heterozygous carriers of the mutation for sickle-cell anemia were subject to
discrimination in employment and insurance, even though they were perfectly healthy.
Skin color is a genetically determined characteristic and there is discrimination against
people with certain skin colors in some societies. Students may have witnessed
discrimination against people with a variety of genetically determined characteristics.
Albinism in humans can be caused by mutations in any one of several different genes.
This situation, in which the same phenotype may result from variation in several different
genes, is referred to as genetic heterogeneity. Is genetic heterogeneity common? Are most
genetic traits in humans the result of variation in a single gene, or are there many genetic
traits that result from variation in several genes, as albinism does?
Possible Answers: Beginning genetics students often have the misconception that most
traits are caused by a single variation at a single gene, much like the traits Mendel studied
in his pea plants. This question provides an opportunity at the beginning of the course to
discuss this misconception and the fact that the genetic basis of most traits is more
complex.
Many genetic traits and diseases exhibit genetic heterogeneity, where DNA sequences at
any one of several different genes can result in the same phenotype. For example,
albinism in the Hopis is caused by mutations in the OCA2 gene, but mutations at several
other genes may produce albinism in other populations. Genetic heterogeneity can also
result from different mutations at the same gene. Both types of heterogeneity are seen in
Chapter 1
Think-Pair-Share questions for the chapter opening story:
Albinism occupied a special place in the Hopi culture; individuals who possessed this
trait were valued by members of the tribe. What are some examples of genetic traits that,
in contrast, sometimes result in discrimination and prejudice?
Possible Answers: People with many genetic traits are exposed to discrimination and
prejudice. Indeed, people with albinism in cultures other than the Hopis are subjected to
discrimination for the way they look. In the past, African Americans who were
heterozygous carriers of the mutation for sickle-cell anemia were subject to
discrimination in employment and insurance, even though they were perfectly healthy.
Skin color is a genetically determined characteristic and there is discrimination against
people with certain skin colors in some societies. Students may have witnessed
discrimination against people with a variety of genetically determined characteristics.
Albinism in humans can be caused by mutations in any one of several different genes.
This situation, in which the same phenotype may result from variation in several different
genes, is referred to as genetic heterogeneity. Is genetic heterogeneity common? Are most
genetic traits in humans the result of variation in a single gene, or are there many genetic
traits that result from variation in several genes, as albinism does?
Possible Answers: Beginning genetics students often have the misconception that most
traits are caused by a single variation at a single gene, much like the traits Mendel studied
in his pea plants. This question provides an opportunity at the beginning of the course to
discuss this misconception and the fact that the genetic basis of most traits is more
complex.
Many genetic traits and diseases exhibit genetic heterogeneity, where DNA sequences at
any one of several different genes can result in the same phenotype. For example,
albinism in the Hopis is caused by mutations in the OCA2 gene, but mutations at several
other genes may produce albinism in other populations. Genetic heterogeneity can also
result from different mutations at the same gene. Both types of heterogeneity are seen in
Answers to Chapter Opening and End-of-Chapter Think-Pair-Share Questions: Pierce Genetics 6e
human albinism. Many genetic traits are also the result of combined variation at several
genes, a situation referred to as a polygenic trait (see Chapters 5 and 24).
End-of-chapter Think-Pair-Share questions:
Section 1.1
1. Bob says that he is healthy and has no genetic diseases such as hemophilia or Down
syndrome. Therefore, genetics, he says, plays little role in his life. Do you think Bob is
correct in his conclusion? Why or why not?
Possible Answers: Bob makes a common mistake when he thinks of genetic effects only
as classical genetic diseases, like hemophilia and Down syndrome. In fact, there are
many common disorders and diseases, as well as variations in healthy phenotypes, that
are influenced by genetics. In many of these cases, the phenotype is the result of a
variation in multiple genes (the trait is polygenic) and the interaction of genes and
environment (see Chapter 5). For example, common diseases, such as asthma, coronary
heart disease, hypertension, depression, and diabetes, are due to a combination of
variations at multiple genes and environmental factors. Many aspects of our appearance,
such as height, weight, facial features, hair color, skin color, and eye color, are also
determined at least to some degree by genetic variation.
2. Are mutations good or bad? Explain your answer.
Possible Answers: This question will likely elicit interesting responses from students.
Mutations might be seen as both good and bad. On the one hand, mutations provide the
necessary genetic variation necessary for evolution, the process by which populations
change and become adapted to their environments. Adaptation and evolutionary change
allow populations to avoid extinction when environments change. So, mutations can be
beneficial to the long-term success of a population. Mutations result in individual
differences, which makes each of us unique. Also, mutations are often useful in genetic
research, as we will see in our journey through the field of genetics. On the other hand,
when mutations result in genetic diseases, they may cause pain and suffering. Thus, many
human albinism. Many genetic traits are also the result of combined variation at several
genes, a situation referred to as a polygenic trait (see Chapters 5 and 24).
End-of-chapter Think-Pair-Share questions:
Section 1.1
1. Bob says that he is healthy and has no genetic diseases such as hemophilia or Down
syndrome. Therefore, genetics, he says, plays little role in his life. Do you think Bob is
correct in his conclusion? Why or why not?
Possible Answers: Bob makes a common mistake when he thinks of genetic effects only
as classical genetic diseases, like hemophilia and Down syndrome. In fact, there are
many common disorders and diseases, as well as variations in healthy phenotypes, that
are influenced by genetics. In many of these cases, the phenotype is the result of a
variation in multiple genes (the trait is polygenic) and the interaction of genes and
environment (see Chapter 5). For example, common diseases, such as asthma, coronary
heart disease, hypertension, depression, and diabetes, are due to a combination of
variations at multiple genes and environmental factors. Many aspects of our appearance,
such as height, weight, facial features, hair color, skin color, and eye color, are also
determined at least to some degree by genetic variation.
2. Are mutations good or bad? Explain your answer.
Possible Answers: This question will likely elicit interesting responses from students.
Mutations might be seen as both good and bad. On the one hand, mutations provide the
necessary genetic variation necessary for evolution, the process by which populations
change and become adapted to their environments. Adaptation and evolutionary change
allow populations to avoid extinction when environments change. So, mutations can be
beneficial to the long-term success of a population. Mutations result in individual
differences, which makes each of us unique. Also, mutations are often useful in genetic
research, as we will see in our journey through the field of genetics. On the other hand,
when mutations result in genetic diseases, they may cause pain and suffering. Thus, many
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